TABLE 3.
CFU in kidney on day 7 postchallenge in mice treated prophylactically with Fungizone or AmBisome 7 days prior to challenge with C. albicans
| Treatment | Dose (mg/kg) | Immunocompetent mice
|
Immunosuppressed mice
|
||
|---|---|---|---|---|---|
| Mean log10 CFU/g of kidney ± SD | No. surviving/total | Mean log10 CFU/g of kidney ± SD | No. surviving/total | ||
| Control | 6.00 ± 0.44 | 5/5 | 6.22 ± 0.73 | 5/5 | |
| Fungizone | 1 | 5.20 ± 0.73 | 5/5 | 4.18 ± 1.20 | 5/5 |
| AmBisome | 1 | 4.59 ± 0.48 | 5/5 | 3.22 ± 0.98 | 5/5 |
| AmBisome | 5 | 3.82 ± 0.24 | 5/5 | 3.46 ± 0.68 | 5/5 |
| AmBisome | 10 | 3.49 ± 0.33 | 5/5 | ||
| AmBisome | 20 | 3.27 ± 0.44 | 5/5 | 2.67 ± 0.79 | 5/5 |