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. 2022 Apr 12;23:127. doi: 10.1186/s12859-022-04674-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The evaluation of TAD boundaries statistically among the considered TAD callers between replicates over normalized human embryonic stem cell line Micro-C dataset at 5kb resolution, having the same sequencing depths. A TAD boundaries reproducibility between technical and biological replicates, as evaluated via Jaccard Index. B TAD count distribution relative to various reproducibility levels for individual TAD callers (Levels of reproducibility are between 8 and 1 from top to bottom). C The mean TAD interaction frequency across various TAD reproducibility levels between samples. D TAD sizes across various TAD reproducibility levels between samples