Table 7.

The ratio of signal variance over the inferrred TADs as evaluated via TAD$adj{R}^2$ among a loci pair across $0-1$M distance

	With corner dot (extrusion loop)			Without corner dot
	Average	Max	Min	Average	Max	Min
Armatus	0.641	0.709	0.524	0.653	0.721	0.535
Arrowhead	0.654	0.740	0.531	0.666	0.751	0.533
CaTCH	0.699	0.759	0.571	0.712	0.773	0.585
Constrained HAC	0.698	0.768	0.568	0.711	0.779	0.579
CHDF	0.654	0.726	0.544	0.667	0.739	0.556
ClusterTAD	0.674	0.741	0.555	0.687	0.755	0.567
deDoc	0.695	0.761	0.573	0.707	0.774	0.585
DI	0.690	0.754	0.568	0.701	0.765	0.582
EAST	0.714	0.801	0.583	0.725	0.813	0.595
GMAP	0.645	0.712	0.527	0.657	0.725	0.540
GRiNCH	0.648	0.715	0.531	0.659	0.728	0.545
HiCExplorer	0.697	0.766	0.573	0.709	0.777	0.586
HiCKey	0.658	0.735	0.549	0.667	0.745	0.559
HiCseg	0.655	0.733	0.544	0.665	0.744	0.556
IC-Finder	0.685	0.752	0.564	0.696	0.761	0.575
InsulationScore	0.665	0.729	0.549	0.678	0.741	0.561
Matryoshka	0.692	0.761	0.565	0.703	0.774	0.578
MrTADFinder	0.631	0.685	0.535	0.642	0.695	0.545
MSTD	0.671	0.736	0.553	0.683	0.748	0.566
OnTAD	0.732	0.799	0.597	0.745	0.812	0.609
Spectral	0.638	0.711	0.519	0.651	0.722	0.531
SpectralTAD	0.645	0.708	0.533	0.656	0.721	0.545
TADBD	0.686	0.753	0.565	0.696	0.763	0.576
TADbit	0.724	0.793	0.594	0.736	0.805	0.605
TADpole	0.670	0.741	0.559	0.685	0.751	0.571
TADtree	0.672	0.738	0.558	0.682	0.748	0.569
TopDom	0.654	0.717	0.541	0.667	0.729	0.553

Multiple TAD callers are evaluated on the interaction dataset normalized by HiCNorm at 5kb resolution over human embryonic stem cell line. Bold numbers show the leading result for every column