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. 2022 Apr 13;8:2. doi: 10.1186/s40733-022-00084-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — A Total cell count in the bronchoalveolar lavage (BAL) were significantly increased in OVA mice and acute neutrophilic inflammation compared to control (P < 0.0001, P < 0.0001), respectively B Serum C1M was significantly increased in serum from OVA mice and mice with an acute neutrophilic inflammation as compared to controls (P < 0.0001, P = 0.0002), respectively. C Correlation between serum C1M level and airway resistance (r = 0.501, p = 0.0005). D Correlation between serum C1M level and airway compliance (r = -0.473, P = 0.0016). E Correlation between serum C1M level and BAL neutrophil was not significant. F Serum C1M levels were decreased in OVA mice treated with CP17, a peptide inhibiting neutrophil accumulation, compared to OVA mice treated with a scrambled peptide (p = 0.047). Data are presented as bar graphs and analyzed using the Kruskal-Wallis test using Dunn’s multiple comparisons or the Mann-Whitney test. The correlation was analyzed using spearman’s correlation. Asterisks indicate statistically significance: *p < 0.05, ***p < 0.001 and ****p < 0.0001