TABLE 1.

Clinical features of the cases with AFF2 mutations.

	Case 1	Case 2	Case 3	Case 4	Case 5
AFF2 mutations (NM_002025.4)	c.230A > T/p.N77I	c.391C > T/p.H131Y	c.1540C > T/p.R514C	c.2009G > A/p.R670H	c.2074C > G/p.P692A
Diagnosis	PE	PE	PE	PE	PE
Gender	Male	Male	Male	Male	Male
Present age	8 yr	9 yr	5 yr	10 yr	27 yr
FS onset age	14 mo	2 yr	18 mo	10 mo	—
aFS onset age	7 yrs	9 yrs	5 yrs	7 yrs	8 yrs
Intermission from FS to EP	6 yrs	7 yrs	4 yrs	7 yrs	—
Seizure type	FS, CPS	FS, CPS	FS, CPS	FS, CPS, sGTCS	CPS, sGTCS
Seizure frequency	FS once, CPS 2 times/mo	FS once, CPS 3 times/mo	FS 4 times, CPS 4–5 times/yr	Prolonged FS 2 times/yr, CPS/sGTCS 3–4 times/yr	CPS 5–6 times/mo, sGTCS 1–2 times/yr
Seizure timing	Nocturnal	Diurnal	Diurnal	Diurnal and nocturnal	Diurnal and nocturnal
Family history of seizure	None	None	None	None	None
Ictal EEG	Generalized spike and spike-slow wave originated from the left mid-central with a partial seizure	NA	Generalized slow wave originated from the left hemisphere with a partial seizure	NA	NA
Interictal EEG	Bilateral spike and slow waves predominantly in the frontal and central areas	Bilateral spike and slow waves predominantly in the frontal and anterior-temporal areas	Spike and slow waves predominantly in the left hemisphere	Bilateral sharp waves predominantly in the occipital areas	Bilateral spike and slow waves predominantly in the frontal areas
Brain MRI	Normal	Normal	Normal	Normal	Normal
Intelligence	Normal	Normal	Normal	Normal	Normal
Developmental delay	No	No	No	No	No
Treatment	LTG	VPA, OXC	LTG	VPA, OXC	VPA, LTG
Seizure outcome	Free for 1 yr	Free for 1 yr	Free for 1 yr	Free for 1 yr	Free for 5 yrs

aFS, afebrile seizures; CPS, complex partial seizure; EEG, electroencephalogram; EP, epilepsy; FS, febrile seizures; LTG, lamotrigine; MRI, magnetic resonance imaging; mo, month; NA, not available; OXC, oxcarbazepine; PE, partial epilepsy; sGTCS, secondary generalized tonic-clonic seizure; VPA, valproate; yr, year.