Table 2: Platelet Aggregation Analysis.

The percentage of platelet aggregation were assessed in all groups at baseline, T6, and days 2, 6, 14 and 21. Control: control group (n5 animals); GMI-1271 TRT: E-selectin inhibitor treatment group (n4 animals). Baseline; T6: 6 hours after thrombosis, Day 2: two days after thrombosis and start of treatments; Day 7: seven days after thrombosis; Day 14: fourteen days after thrombosis; Day 21: twenty-one days after thrombosis and end of study. In parenthesis are standard error of mean (SEM) values. Direct comparisons between the groups showed no significant differences.

Dense Granule Secretion (nM ATP release) 1nM Thrombin
	CONTROL	GMI-1271 TRT
BASELINE	0.29 (0.2)	0.20 (0.2)
T6	0.12 (0.1)	0.23 (0.2)
Day 2	0.28 (0.1)	0.16 (0.1)
Day 7	0.16 (0.1)	0.03 (0.0)
Day 14	0.03 (0.0)	0.07 (0.1)
Day 21	0.27 (0.2)	0.42 (0.3)

Dense Granule Secretion (nM ATP release) 2nM Thrombin
	CONTROL	GMI-1271 TRT
BASELINE	0.67 (0.2)	0.34 (0.2)
T6	0.19 (0.1)	0.34 (0.1)
Day 2	0.47 (0.1)	0.42 (0.1)
Day 7	0.34 (0.2)	0.07 (0.1)
Day 14	0.23 (0.1)	0.19 (0.1)
Day 21	0.56 (0.3)	0.68 (0.2)