. Author manuscript; available in PMC: 2022 Apr 13.

Published in final edited form as: J Vasc Surg Venous Lymphat Disord. 2020 Mar;8(2):268–278. doi: 10.1016/j.jvsv.2019.08.016

Table 3: Dense Granule Secretion Analysis.

Platelet dense granule secretion were assessed in all groups at baseline, T6, and days 2, 6, 14 and 21. Control: control group (n5 animals); GMI-1271 TRT: E-selectin inhibitor treatment group (n4 animals). Baseline; T6: 6 hours after thrombosis, Day 2: two days after thrombosis and start of treatments; Day 7: seven days after thrombosis; Day 14: fourteen days after thrombosis; Day 21: twenty-one days after thrombosis and end of study. In parenthesis are standard error of mean (SEM) values. Direct comparisons between the groups showed no significant differences.

Platelet Aggregation (%) 1nM Thrombin
	CONTROL	GMI-1271 TRT
BASELINE	32 (17.1)	43 (13.7)
T6	44 (15.5)	45 (18.0)
Day 2	72 (10.3)	67 (21.6)
Day 7	62 (24.3)	30 (12.5)
Day 14	23 (12.3)	34 (13.3)
Day 21	41 (19.2)	43 (21.3)

Platelet Aggregation (%) 2nM Thrombin
	CONTROL	GMI-1271 TRT
BASELINE	72 (3.7)	68 (6.2)
T6	58 (21.5)	76 (6.3)
Day 2	88 (4.5)	87 (3.9)
Day 7	76 (15.7)	51 (21.7)
Day 14	56 (23.5)	60 (10.4)
Day 21	63 (14.7)	67 (11.8)