Table 3.

Ketamine-based management of naxitamab-induced pain at HSJD

Timing	Midazolam	Lidocaine	Atropine	Ketamine
Before infusion	0.05 mg/kg i.v. bolus	≤40 kg: bolus >40 kg: bolus	0.005 mg/kg i.v. bolus	0.5 mg/kg i.v. bolus
During infusion	—	Minute 15: additional bolus	PRN: additional bolus	Minute 15: 1-2 mg/kg i.v. bolus; added doses up to a total of 4 mg/kg

Ketamine was administered to patients if prior supportive therapy with opioids did not provide adequate support.

HSJD, Hospital Sant Joan de Déu; i.v., intravenous; PRN, as needed.