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Antibody-dependent cellular cytotoxicity mediated by Fc variants
| 4D5 variants | EC50 (ng/ml) |
||||
|---|---|---|---|---|---|
| pH 6.5 | 95% CI | pH 7.4 | 95% CI | Selectivity (pH 7.4/pH 6.5) | |
| WT | 96.28 | 37.72–200.8 | 101.4 | 30.24–165.3 | 1.05 ± 1.03 |
| Acid-Fc | 120.7 | 25.99–437.0 | 2307 | 813.7–6926 | 19.1 ± 2.5 |
Four-parameter logistic curves were fit to the ADCC dose-response curves with GraphPad to obtain the EC50 values and 95% confidence intervals shown. Selectivity was calculated by EC50 at pH 7.4 divided by EC50 at pH 6.5.
