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. 2022 Mar 3;298(4):101791. doi: 10.1016/j.jbc.2022.101791

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© 2022 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Phylogenetic grouping of human mitochondrial protein MTases. An unrooted phylogenetic tree of human mitochondrial protein MTases (bold) and their closest human relatives is shown. Blue indicates members of Methyltransferase Family 16, green the inter-related ANT-KMT and ATPSc-KMT that are similar to archaeal KMTs, pink the group formed by CS-KMT and three eEF1A-specific KMTs, and beige HEMK1 and its cytosolic counterpart HEMK2/N6AMT1. First, a sequence alignment of the relevant sequences was generated using MAFFT (133), and then a tree generated and rendered using the PhyML and TREEDYN programs, respectively, both found as part of the Phylogeny.fr package (134, 135, 136). KMT, lysine specific MTase; MTase, methyltransferase.