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. Author manuscript; available in PMC: 2022 Dec 1.
Published in final edited form as: Curr Opin Genet Dev. 2021 Jul 28;71:99–105. doi: 10.1016/j.gde.2021.07.004

Figure 1: DSB are repaired by NHEJ or HR.

Figure 1:

While NHEJ directly re-ligates DSBs, HR requires nucleolytic processing of the DSB ends by MRX-mediated initial and Exo1 or STR (Sgs1-Top3-Rmi1)-Dna2-mediated long-range resection. The ssDNA generated is coated by RPA and subsequently bound by the Rad51 recombinase for strand invasion and repair synthesis. The S. cerevisiae protein names are shown. See text for homologs in other organisms.