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. 2022 Mar 30;13:863646. doi: 10.3389/fphar.2022.863646

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Copyright © 2022 Ding, Hou, Liu, Yu, Cui and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ScRNA-seq analysis of BLM-induced PF. (A) Identified cell types in UMAP. (B) Cells split by inflammatory and fibrotic phases. (C) Percentage of macrophages. Bubble/bar plot showing GO/KEGG enrichment analysis results of the (D) downregulated and (E) upregulated genes in macrophages. (F) Percentage of fibroblasts. Bubble/bar plot showing GO/KEGG enrichment analysis results of the (G) downregulated and (H) upregulated genes in fibroblasts. (I) Percentage of epithelial cells. Bubble/bar plot showing GO/KEGG enrichment analysis results of the (J) downregulated and (K) upregulated genes in epithelial cells. *p < 0.05, ***p < 0.001, versus the control group, by the Mann–Whitney U test.