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Diagram of miR-130a-3p on PF in inflammatory and fibrotic phases. In the inflammatory phase, activation of the NF-κB signaling pathway increases the expression of miR-130a-3p, while overexpression of miR-130a-3p inhibits LPS-induced production of TNF-α. In the fibrotic phase, TGF-β1 decreases miR-130a-3p expression through the TGF-β1/Smad pathway. Meanwhile, miR-130a-3p targets TGF-βRII and therefore inhibits the TGF-β1/Smad pathway.
