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. 2022 Mar 30;13:863646. doi: 10.3389/fphar.2022.863646

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Copyright © 2022 Ding, Hou, Liu, Yu, Cui and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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BLM induces the expression of inflammation- and fibrosis-related protein. (A) qRT-PCR quantitation of mRNA expressions of inflammation-related genes. **p < 0.01, ***p < 0.001, -versus the control group, one-way ANOVA followed by Bonferroni’s test, n = 3–6. (B) qRT-PCR quantitation of mRNA expressions of fibrosis-related genes. *p < 0.05, versus the control group, by the Mann–Whitney U test, n = 3–6. (C-D) Representative and statistical data of inflammation-related proteins. **p < 0.01, ***p < 0.001, versus the control group, by the Mann–Whitney U test, n = 4–5. (E-F) Representative and statistical data of fibrosis-related proteins. *p < 0.05, **p < 0.01, ***p < 0.001, versus the control group, by the Mann–Whitney U test, n = 3–5.