Fig. 3.

Multinucleated giant cells are readily detected in lung granulomas. Representative images of H&E stained lung sections from adjuvant control (A) and vimentin-immunized (B–D) mice are shown. (C) Multinucleated giant cells (MGC) are seen in and around the granuloma (arrows) and are increased in vimentin-immunized mice. (D) A higher magnification image of inset in C showing Langhans (LGC) and Foreign body giant cells (FBGC) in the granulomas. Scale bar = 50 μm. (E) The number of MGC was quantified in 4 discrete areas of 1.25 mm² in one section for each mouse, and the results are represented as MGC per sq mm. (F). A robust correlation between the numbers of Foreign body and Langhans GC is noted in vimentin-immunized mice.