TABLE 1.
Behavioral outcomes after manipulation of neural circuits using different social and non-social behavioral paradigms.
| Behavior | Manipulation in cited articles | Social recognition | Object recognition | Olfaction test | |||||
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| Article | Two-trial | Three Chamber | Five-trial | One-trial | Resident-intruder | Novel object recognition | Olfactory habituation/dishabituation | Buried food | |
| Kogan et al. (2000) | Whole HPC lesion | + | − | − | − | − | − | − | − |
| Hitti and Siegelbaum (2014) | dCA2 inhibition | + | + | + | − | − | + (*) | + | + |
| Stevenson and Caldwell (2014) | CA2 silence | + | − | + | − | − | − | + | + |
| Meira et al. (2018) | dCA2, dCA2-vCA1 inhibition | + | + | − | − | − | − | − | − |
| Okuyama et al. (2016) | vCA1, vCA1-NAc inhibition | − | − | − | + | + | +(*) | − | − |
| Deng et al. (2019) | PVIs inhibition in vCA1 PVIs activation in vCA1 | − | + | − | + | − | + (Ns) | − | − |
| Phillips et al. (2019) | vHPC-mPFC inhibition in WT vHPC-mPFC inhibition in Mecp2 | − | + | − | + | − | +(*) | − | − |
| Chen et al. (2020) | SuM-dCA2 activation | + | − | + | − | − | − | − | − |
| Wu et al. (2021) | MS, MS- dCA2 inhibition | + | + | + | − | − | +(*) | − | − |
| Tanimizu et al. (2017) | Protein synthesis inhibition of mPFC, ACC, BLA | + | − | − | − | − | − | − | − |
| Sun et al. (2020) | PVIs activation in mPFC | − | − | − | + | − | +(*) | − | − |
| Almeida-Santos et al. (2019) | OB, dHPC inhibition | + | − | − | − | − | − | − | − |
| Park et al. (2021) | NAc-IL inhibition NAc-IL activation | − | + | − | − | − | +(*) | − | − |
| Ferguson et al. (2000) | Oxytocin knockout mice | + | − | + | − | − | − | + | − |
| Lee et al. (2008) | OXTRs knockout mice | + | − | + | − | − | − | − | − |
| Bielsky et al. (2005) | VAPRs knockout mice | + | − | + | − | − | − | + | − |
| Ferguson et al. (2002) | Oxytocin and vasopressin treatment | + | − | + | − | − | − | − | − |
| Raam et al. (2017) | Viral recombination of OXTRs in anterior DG, CA2, CA3 | − | − | − | + | − | +(*) | − | − |
| Lin et al. (2018) | Conditional deletion of the OXTRs in CA2/CA3 | − | + | + | − | − | − | − | − |
| Chiang et al. (2018) | vCA3 inhibition | + | + | − | − | − | +(*) | − | − |
+Behavior performed –Behavior not performed. Two-trial: Two-trial social recognition paradigm in Figure 2A. Five-trial: Social habituation-dishabituation paradigm in Figure 2B. One-trial: Social discrimination paradigm in Figure 2C.
*Represents that both experimental and control groups have a significant difference between the investigation time of the novel object and the familiar object, indicating the intact object recognition memory. Ns means that experimental groups have no difference between the investigation of the novel object and the familiar object while the object recognition memory in the control groups remained unaffected, indicating the impaired object recognition memory. PVIs: Parvalbumin (PV) interneurons; Oxytocin receptors: OXTRs; Vasopressin 1a receptors: VAPRs.