TABLE 1.

Quantitative organ culture results from in vivo infection with C. albicans

Drug	Dose (mg/kg/day)	Delivery route	No. of survivorsa	Organ load (CFU/g of tissue)e
				Kidneys	Lungs
Trial 1
Controlb	0	PO	0	110 ± 18 × 105	204 ± 45 × 102
DAMB	2	IP	10	20 ± 4 × 102	0
CAMB	0.5	PO	10	100 ± 16 × 103	15 ± 7 × 101
CAMB	1	PO	10	503 ± 96 × 102	3 ± 5 × 101 (7)
CAMB	2.5	PO	10	26 ± 8 × 102 c,d	0
CAMB	5	PO	10	12 ± 6 × 102 c,d	0
Trial 2
Control	0	PO	0	121 ± 48 × 105	172 ± 87 × 102
DAMB	1	IP	7	496 ± 71 × 102	28 ± 57 × 102 (7)
LAMB	10	PO	9	275 ± 216 × 102	6 ± 7 × 101 (5)
CAMB	5	PO	10	13 ± 8 × 102 c,d (1)	0
CAMB	10	PO	10	28 ± 31 × 102 c,d	0
CAMB	20	PO	10	26 ± 48 × 102 c,d (2)	0

^aSurviving animals, out of a total group of 10, on day 16. 

^bAnimals treated PO with empty cochleates. 

^cP < 0.01 compared with results for the respective control mice. 

^dP < 0.05 compared with results for the respective DAMB at 2 mg/kg/day. 

^eNumbers in parentheses indicate the number of animals with undetectable colony counts.