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. 2022 Mar 30;13:812065. doi: 10.3389/fphar.2022.812065

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Copyright © 2022 Huynh, Seeland, Segrestaa, Gnerre, Hogeback, Meyer zu Schwabedissen, Dingemanse and Sidharta.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Arithmetic mean (+SD) concentration vs. time profile of total ¹⁴C-radioactivity in plasma on linear and semilog (inset) scale following a single oral administration of 9.2 μg ¹⁴C-ACT-1004-1239 on top of 100 mg non-radioactive ACT-1004-1239 (N = 6).