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. 2022 Mar 30;13:812065. doi: 10.3389/fphar.2022.812065

TABLE 2.

Summary of relative abundance of ACT-1004-1239 and its metabolites.

Compound ID Plasma Urine Feces Urine + feces
% in sample % in sample % of dose a % in sample % of dose a % of dose
ACT-1004-1239 53.9 69.6 10.1 7.5 5.2 15.3
M1 10.3 9.7 1.4 34.1 23.7 25.1
M23 21.1 - - - - -
A1 - - - 5.8 4.0 4.0
A2 - - - 22.0 15.3 15.3
A3 - - - 3.9 2.7 2.7
Other b 14.7 20.7 3.0 26.7 18.6 21.6
Total - - 14.5 - 69.6 84.1
a

Calculations were based on geometric mean of total cumulative excretion in urine/feces.

b

Refers to the sum of metabolites with a relative abundance of <5%.