Table 2.
Summary of top enriched gene sets by GSEA and GSVA (using all genes) in the MPBCS cohort.
| Enriched in first condition | Enriched in second condition | |
|---|---|---|
| LumA vs Basal | Estrogen response | Cell cycle and mitosis (including TP53 activity) |
| Peroxisoma/fatty acid metabolism | DNA replication | |
| Synthesis of glycosylphosphatidylinositol | MYC targets | |
| Biological oxidations | ||
| LumB vs Basal | Estrogen response | Control of morphogenic processes |
| Peroxisoma/fatty acid metabolism | Cell-cell communication | |
| Sumoylation of intracellular receptors | Signaling by EGFR | |
| Biological oxidations | ||
| LumA vs HER2E | Estrogen response | Cell cycle and mitosis (including TP53 activity) |
| Growth factor signaling (ERBB4, FGFR, ILGF, PI3K cascades) | DNA replication | |
| MYC targets | ||
| PTEN regulation of stability and activity | ||
| LumB vs HER2E | Estrogen response | Extracellular matrix organization/collagen assembly |
| DNA repair | Signaling by ERBB2 | |
| Synthesis of glycosylphosphatidylinositol | Signaling by EGFR | |
| MAPK signaling pathway | ||
| Cell adhesion and migration | ||
| LumA vs LumB | Extracellular matrix organization | Cell cycle and mitosis (including TP53 activity) |
| Cell-cell and cell-matrix adhesion | DNA replication | |
| PI3K-AKT signaling in cancer | MYC targets | |
| MAPK signaling pathway | ||
| Myogenesis and muscle contraction | ||
| HER2E vs Basal | Peroxisome/Fatty acid metabolism/steroid biosynthesis | Cell cycle and mitosis (including TP53 activity) |
| Biological oxidations | MYC targets | |
| Xenobiotic metabolism | Intracellular transport | |
| Downregulation of ERBB2 signaling | ||
| Androgen response |