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. 2022 Mar 30;9:858603. doi: 10.3389/fnut.2022.858603

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Copyright © 2022 Zhang, Wu, Zhao, Yang, Chen, Wang, Wang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Imaging MS visualize the zonation patterns of BA metabolism in liver of HFD-fed mice. MS ion images representing spatial distributions of the identified taurine-conjugated BAs at m/z 498.2895 ± 0.05 (TCDCA/TUDCA/TDCA) and m/z 514.2844 ± 0.05 (TCA/TMCA) for the mouse liver in same tissue section at high spatial resolution. Overlay: Overlay of each MS ion image and optical image. All ion images were normalized to the 9AA matrix signal. The green arrows indicated bile ducts, whereas the red arrows showed blood vessels. Scale bars: 250 μm.