Fig. 3.

Impacts of phenotypic characteristics on diagnostic solution rates. A, Individual clinical and audiologic characteristics impact the diagnostic rates. Color shading indicates five clinical and audiologic categories: inheritance, hearing loss onset, hearing loss grade, laterality, and ethnicity. The dashed line indicates the overall diagnostic rate for this study (25%). The bars in the column chart indicate the percentages of patients with the noted individual characteristics in the five categories (the number of patients is noted for each characteristic). Statistical significance was determined with Fisher’s exact test (*p < 0.05 and **p < 0.005). B, Combination of above-average clinical and audiological characteristics impacts the diagnostic rates. Sequential addition of phenotypic criteria to inheritance leads to a stepwise increase in the diagnostic rate (the number of patients is noted for each characteristic). Statistical significance was determined with Fisher’s exact test (*p < 0.05; **p < 0.005). Adapted from Sloan-Heggen et al. (2016).