Fig. 4.

Distribution of 35 genes among 70 clinically relevant (pathogenic, likely pathogenic) variants among 75 solved cases. A, Pie chart of the overall gene distribution. B, Pie chart of the gene distribution for autosomal-recessive genes. C, Autosomal-dominant genes. D, Variant distribution for all cases (n = 305) of 443 different variants from a total of 106 different genes. Classification as pathogenic, likely pathogenic, variants of unknown significance, likely benign and benign according to ACMG/AMP criteria for hearing loss (Oza et al. 2018; Richards et al. 2015).