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In vivo target engagement and concentrations of compound 27 in an H460 NSG mouse xenograft model. Compound 27 (bis-hydrochloride) was administered orally at the indicated doses in an 0.5% aqueous methylcellulose vehicle. There were six animals per group. (a) Glutamate:glutamine ratios at 8 hours and 24 hours after each dose, with standard deviation bars; (b) Free plasma concentrations, with standard deviations, of compound 27 at 8 hours and 24 hours for each dose.
