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. 2022 Mar 30;16:872228. doi: 10.3389/fnins.2022.872228

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Copyright © 2022 Li, Wang, Liu, Liu and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of subcortical volumes between the two groups, and correlations between subcortical volumes and HAMD scores in MMD patients. Top panel: The gray matter volumes of the left thalamus, right thalamus, and right amygdala were significantly smaller in MMD patients than in HCs (*p < 0.006; Bonferroni corrected). Bottom panel: Right amygdala volume was significantly negatively correlated with HAMD score, whereas the left and thalamus volumes were not related to HAMD score in MMD patients. MMD, mild-to-moderate depression; HCs, Healthy Controls.