Table 2.
Study outcomes.
| Parameter | No. of studies | Events/participants | Events | Heterogeneity between trials | P-value for differences across groups | |||
|---|---|---|---|---|---|---|---|---|
|
|
|
|
||||||
| Vitamin D supplementation | Non-vitamin D supplementation | Odds ratio | 95% CI | P-value | I2 statistic | |||
| Mechanical ventilation | 2 | 9/139 (6.5%) | 60/317 (1.9%) | 0.38 | 0.17 to 0.86 | 0.48 | 0% | 0.02 |
| Radiological worsening | 1 | 2/19 (10.5%) | 56/197 (28.4%) | 0.30 | 0.07 to 1.32 | NA | NA | 0.11 |
| Secondary infection | 1 | 2/19 (10.5%) | 44/197 (22.3%) | 0.41 | 0.09 to 1.84 | NA | NA | 0.24 |
| Thrombotic events | 1 | 1/19 (5.3%) | 10/197 (5.1%) | 1.04 | 0.13 to 8.58 | NA | NA | 0.97 |
| ICU admission | 5 | 42/653 (6.4%) | 178/760 (23.4%) | 0.19 | 0.06 to 0.54 | 0.002 | 77% | 0.002 |
| Mortality: | ||||||||
| 14 days mortality | 1 | 3/16 (18.8%) | 10/32 (31.3%) | 0.51 | 0.12 to 2.19 | NA | NA | 0.36 |
| In-hospital mortality | 7 | 42/750 (5.6%) | 220/1,370 (16.1%) | 0.56 | 0.23 to 1.37 | 0.002 | 74% | 0.20 |
CI — confidence interval; ICU — intensive care unit; NA — not applicable