Table 2.
Main clinical variables and echocardiographic parameters in groups AC+ and AC−.
| AC+ | AC− | P | |
|---|---|---|---|
| Number of patients | 14 | 71 | |
| Age [years] | 50.1 ± 9.5 | 51.6 ± 9.03 | 0.78 |
| Body mass index [kg/m2] | 28.01 ± 4.6 | 28.23 ± 4.9 | 0.87 |
| Basal LVEF [%] | 65.5 ± 5.4 | 67.4 ± 6.0 | 0.67 |
| Hypertension | 35.7 | 29.6 | 0.75 |
| Diabetes | 14.3 | 11.3 | 0.67 |
| Hyperlipidemia | 14.3 | 16.9 | 0.58 |
| Smoking | 42.9 | 32.4 | 0.74 |
| Anthracycline dose [mg/m2] | 243 ± 4.8 | 242 ± 4.6 | 0.73 |
| Radiotherapy [%] | 42.9 | 42.3 | 0.97 |
| Radiotherapy total dose [cGy] | 6400.00 | 5823.08 | 0.08 |
| Baseline strain | 18.88 ± 2.9 | 18.91 ± 2.9 | 0.86 |
| Beta-blockers treatment [%] | 14 | 0 | 0.03 |
| ACEI treatment [%] | 7 | 17 | 0.68 |
| Statin treatment [%] | 14 | 13 | 0.87 |
Values are expressed as mean ± standard deviation; values of P calculated by Student’s t for the differences in means between groups AC+ and AC. AC+ — group of patients who develop anthracycline cardiotoxicity; AC− — group of patients who do not develop cardiotoxicity due to anthracyclines; LVEF — left ventricular ejection fraction; ACEI — angiotensin-converting enzyme inhibitors