TABLE 1.

Estimated model parameters (the full list of parameters is provided in Table S1)

Rate	Estimate (1/day)	Estimated 95% CI
r5L, r6L	7.3 × 10−6	(0.47–12) × 10−6
r5M, r6M	0.60 × 10−6	(0.3–1.5) × 10−6
r5H, r6H	0.58 × 10−6	(0.3–1.4) × 10−6
r13L	10.1	0.5–27.7
r13M	0.018	0.002–0.04
r13H	7.4	1.1–20.1

Note: All of the estimates are computed considering the data reported in Byrne et al. ²³ Martinez‐Morillo et al. ¹⁶ and De Schaepdryver et al. ²⁴ for neurofilament light chain, neurofilament medium chain, and phosphorylated neurofilament heavy chain, respectively. The estimate values are derived from the median neurofilament concentrations, whereas the CIs were obtained by repeated calibrations of neurofilament levels randomly selected from the measured ranges.

Abbreviation: CI, confidence interval.