TABLE 2.
Summary of the sensitivity analysis for NfL
| NfL CNS neurons | NfL PNS | NfL ISF | NfL endoneurial fluid | NfL CSF cranial | NfL CSF spinal | NfL blood |
|---|---|---|---|---|---|---|
| r1 | r3 | Age | Age | Age | Age | Age |
| r2 | r4 | r7 | r8 | r1 | r1 | Blood vol. |
| Age | Age | r1 | r3 | r2 | r2 | r13 |
| r5 | r6 | CNS neurons vol. | Motor neurons vol. | r3 | r3 | r1 |
| r7 | r5 | r2 | r4 | r4 | r4 | r2 |
| r9 | r7 | r5 | r6 | CNS neurons vol. | r12 | r3 |
| r10 | r9 | CSF cranial vol. | Endoneurial fluid vol. | r5 | Motor neurons vol. | r4 |
| r11 | r10 | ISF vol. | CSF spinal vol. | r11 | r6 | CNS neurons vol. |
| r12 | r11 | Endoneurial fluid vol. | ISF vol. | r9 | CNS neurons vol. | r5 |
| r6 | r12 | r9 | r12 | r10 | r5 | r6 |
| r8 | r8 | r12 | r10 | Motor neurons vol. | r11 | Motor neurons vol. |
| r13 | r13 | r8 | r9 | r6 | r9 | Endoneurial fluid vol. |
| CNS neurons vol. | CNS neurons vol. | r10 | r5 | r12 | r10 | CSF cranial vol. |
| ISF vol. | ISF vol. | Motor neurons vol. | CSF cranial vol. | Endoneurial fluid vol. | Endoneurial fluid vol. | r7 |
| Motor neurons vol. | Motor neurons vol. | r11 | CNS neurons vol. | CSF cranial vol. | CSF cranial vol. | ISF vol. |
| Endoneurial fluid vol. | Endoneurial fluid vol. | r6 | r7 | ISF vol. | ISF vol. | r10 |
| CSF cranial vol. | CSF cranial vol. | CSF spinal vol. | r11 | r7 | r7 | r9 |
| CSF spinal vol. | CSF spinal vol. | r13 | r13 | r8 | r8 | r12 |
| Blood vol. | Blood vol. | Blood vol. | Blood vol. | CSF spinal vol. | CSF spinal vol. | r11 |
| r3 | r1 | r3 | r1 | r13 | r13 | r8 |
| r4 | r2 | r4 | r2 | Blood vol. | Blood vol. | CSF spinal vol. |
Note: Similar results can be computed for the other two neurofilament subunits. For each compartment, the parameters are sorted from the most relevant to the least relevant. The color map reflects the computed sensitivity values. White cells correspond to very low or negligible sensitivity values.
Abbreviations: CNS, central nervous system; CSF, cerebrospinal fluid; ISF, interstitial fluid; NfL, neurofilament light chain; PNS, peripheral nervous system; vol., volume.