Table 2.

Univariable and multivariable analyses for factors associated with EAD

	Univariable analysis				Multivariable analysis
	OR	95%CI		P	OR	95%CI	P
Recipient preoperative factors
Recipient age, per 10 years*	0.803	0.638–1.011		0.061	0.824	0.650–1.046	0.112
Recipient sex, male	0.434	0.239–0.786		0.006	0.510	0.261–0.996	0.048†
Fulminant hepatic failure	3.205	0.743–13.834		0.119
AST, per 1 IU/L*	0.999	0.995–1.004		0.925
ALT, per 1 IU/L*	0.998	0.992–1.004		0.429
Total-bilirubin clearance*‡	0.936	0.824–1.063		0.312
Albumin, g/dL*	0.875	0.537–1.427		0.593
Creatinine, mg/dL*	1.138	0.823–1.574		0.432
Hepatorenal syndrome	1.692	0.622–4.602		0.303
Donor factors
Donor age, per 5 year*	1.116	0.999–1.247	0.049		1.146	1.016–1.292	0.023†
GRWR, per 0.1%*	0.898	0.783–1.030	0.120
Blood type incompatible donor	0.804	0.407–1.589	0.531
Left lobe graft	1.934	1.074–3.481	0.028		1.740	0.880–3.441	0.112
Intraoperative parameters
Blood loss, per 1L*	0.992	0.954–1.031	0.669
Cold ischemia time, per 1 h*	0.848	0.681–1.055	0.119
P/F ratio at the start of operation <300	0.703	0.380–1.303	0.263
P/F ratio at the start of operation <400	1.104	0.613–1.991	0.740
cFiO2 ≥0.5	2.024	1.020–4.018	0.044		2.038	0.992–4.186	0.053
Final PVP ≥15 mmHg	0.897	0.393–2.044	0.794

^*The factor is included in the analysis as continuous data. Calculated FiO₂ (cFiO₂) was defined as {O₂(L) + Air(L) × 0.21}/{O₂(L) + Air(L)}. †P <0.05 on multivariate analysis. ‡The formula for total bilirubin clearance is as follows: (preoperative bilirubin–POD7 bilirubin)/preoperative bilirubin

ALT alanine aminotransferase; AST aspartate aminotransferase; CI confidence interval; EAD early allograft dysfunction; FiO₂ fraction of inspiratory oxygen; GRWR graft-to-recipient weight ratio; OR odds ratio; P/F PaO₂/FiO₂ ratio; PVP portal vein pressure