Table 2.

Differential exosomal microRNA (miRNA) expression in serum and cerebrospinal fluid (CSF) samples of Parkinson's disease (PD), neurodegenerative disorder (ND), and control subjects.

miRNA member	Serum				miRNA member	CSF
	PD VS control		PD VS ND			PD VS control		PD VS ND
hsa-mirName	FC (log2)	Adjusted p value	FC (log2)	Adjusted p value	has-mirName	FC (log2)	Adjusted p value	Fold change (log2)	Adjusted p value
	Up + 17	Dn- = 10				Up + 19	Dn- = 8
hsa-miR-151a-5p	1.37	0.0042	0.74	0.313	hsa-miR-151a-5p	1.31	0.0073	0.51	0.035
hsa-miR-24	2.31	0.0074	−0.96	0.131	hsa-miR-24	1.62	0.0028	−0.19	0.173
hsa-miR-485-5p	1.95	0.0032	−0.78	0.061	hsa-mir-485-5p	1.79	0.0087	−0.56	0.169
hsa-miR-331-5p	1.63	0.0024	−0.27	0.042	hsa-mir-331-5p	1.43	0.0067	1.34	0.231
hsa-mir-214	1.45	0.0064	0.85	0.067	hsa-mir-214	2.18	0.0013	0.37	0.052
hsa-miR-29b-2-5p	−1.56	0.0086	−0.63	0.008	hsa-mir-1	−0.75	0.0043	0.63	0.042
hsa-miR-29c	1.43	0.0053	0.74	0.045	hsa-let-7b	1.23	0.0023	0.72	0.013
hsa-miR-16-2-3p	2.04	0.0042	−0.24	0.141	hsa-let-7f-1-3p	0.84	0.0075	0.13	0.143
hsa-let-7d-5p	−1.42	0.0065	0.68	0.042	hsa-mir-103a	−0.64	0.0054	−0.63	0.125
hsa-miR-200a	1.43	0.0021	−0.24	0.214	hsa-mir-127-3p	1.62	0.0022	0.76	0.315
hsa-miR-126	1.39	0.0089	0.34	0.061	hsa-mir-136-3p	−0.63	0.0095	−0.28	0.531
hsa- miR-221	0. 91	0.0024	−0.15	0.162	hsa-mir-151	1.56	0.0044	−0.47	0.173
hsa- miR-148b	−0.76	0.0086	0.85	0.341	hsa-mir-153	−0.72	0.0093	−0.63	0.251
hsa- miR-19a	1.02	0.0086	−0.46	0.142	hsa-miR-16	1.53	0.0031	−0.71	0.152
hsa-miR-29b	−0.84	0.0032	0.09	0.041	hsa-mir-16-2	1.46	0.0064	0.08	0.173
hsa-miR-126a	2.46	0.0065	−0.85	0.085	hsa-miR-200a-3p	1.08	0.0046	0.38	0.663
hsa-miR-151-5p	−0.82	0.0087	0.47	0.231	hsa-miR-200a-5p	2.42	0.0043	−0.21	0.113
hsa- miR-24	1.18	0.0079	−0.41	0.062	hsa-mir-22	2.31	0.0015	−0.52	0.085
hsa-miR-374a	−0.73	0.0067	0.65	0.184	hsa-mir-26a	−1.35	0.0065	−0.63	0.352
hsa-miR-15b	−0.16	0.0096	0.54	0.042	hsa-miR-26a-5p	1.86	0.0032	0.82	0.374
hsa-let-7a	0.66	0.0041	−0.96	0.139	hsa-mir-29	1.24	0.0065	0.48	0.139
hsa-miR-29a-3p	−0.43	0.0085	0.85	0.045	hsa-miR-29b-1	1.21	0.0028	−0.46	0.421
hsa- miR-626	−0.84	0.0069	0.52	0.101	hsa-mir-30b	0.84	0.0054	−0.51	0.732
hsa-miR-301a	2.71	0.0022	0.55	0.126	hsa-miR-331-3p	−0.72	0.0025	−0.52	0.024
hsa-miR-28-5p	1.31	0.0046	−0.71	0.272	hsa-mir-374	2.04	0.0026	1.06	0.214
hsa-miR-1	−0.34	0.0085	0.87	0.168	hsa-mir-409-3p	−1.12	0.0086	−0.09	0.118
hsa- miR-29c	0.96	0.0053	1.39	0.172	hsa-miR-485-3p	−0.44	0.0034	0.87	0.031

VS = versus; FC = fold change; Dn Downregulated; hsa-miR = human miRNA; PD = Parkinson's disease; ND = neurodegenerative disease.