Fig. 3.

Pharmacokinetics, bioactiv-ity, and toxicity of polyphenols. LR, pharmacokinetic score based on Lipinski’s rule; VR, bioavailability score based on Veber’s rule; DS, drug-score; GPCRL, G protein-cou-pled receptor ligand; ICM, ion channel modulator; KI, kinase inhibitor; NRL, nuclear receptor ligand; PI, protease inhibitor; EI, enzymatic inhibitor; M, mutagenic; T, tumorigenic; I, irritant; R, reproductive. For LR, the color indicates the number of violations to the rule: red (≥2), yellow (1), green (0); for VR, green indicates abidance by the rule; for DS, red (<33%), yellow (33%∼66%), green (>66%); for GPCRL, ICM, KI, NRL, PI, and EI, red (no activity), yellow (low activity), green (medium activity); for M, T, I, and R, green (no risk), yellow (moderate risk), red (high risk).