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. Author manuscript; available in PMC: 2022 Sep 2.
Published in final edited form as: Nat Struct Mol Biol. 2022 Mar 2;29(3):229–238. doi: 10.1038/s41594-022-00735-5

Figure 7. Schematic of the energy landscape for the SARS-CoV-2 Spike ectodomain.

Figure 7.

Reaction coordinate illustrating the different conformations accessible by Spike. Three different conformational states are depicted: the canonical prefusion ensemble, the expanded open trimer, and the postfusion conformation. The prefusion conformation contains all four RBD states (0,1,2, or 3 up). The relative energies and barrier heights as well as the placement of the open trimer along the reaction coordinate are drawn for illustration only.