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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Semin Cancer Biol. 2021 Oct 17;81:132–144. doi: 10.1016/j.semcancer.2021.10.005

Fig. 5. Strategies that target the giant cell life cycle for prevention and therapy.

Fig. 5.

Phases of the giant cell life cycle are illustrated in response to therapeutic stress, followed formation of blastocyst-like structure for embryonic diapause for dormancy, and then awakening for resistance and metastasis. Specific strategies to block each phase of the giant cell life cycle including the differentiation therapy are shown in the diagram.