Table 3.

Univariate and multivariable predictors of event-free and overall survival among patients with B-ALL

	Event-free Survival				Overall Survival
	Univariate		Multivariable		Univariate		Multivariable
	HR (95CI)	P value	HR (95CI)	P value	HR (95CI)	P value	HR (95CI)	P value
Age at diagnosis (years)
<10	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
≥10	2.7 (2.4–2.9)	<0.0001	1.7 (1.5–1.9)	<0.0001	4.1 (3.6–4.8)	<0.0001	2.5 (2.2–3.0)	<0.0001
Sex
Female	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Male	1.2 (1.1–1.3)	0.003	1.2 (1.1–1.3)	0.004	1.2 (1.0–1.3)	0.047	1.2 (1.0–1.4)	0.046
WBC at presentation (×109/L)
<50	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
≥50	2.1 (1.9–2.4)	<0.0001	1.6 (1.4–1.8)	<0.0001	2.3 (2.0–2.7)	<0.0001	1.5 (1.3–1.8)	<0.0001
CNS status
CNS1	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
CNS2	1.8 (1.5–2.0)	<0.001	1.4 (1.2–1.6)	<0.0001	1.9 (1.6–2.3)	<0.0001	1.4 (1.1–1.7)	0.002
CNS3	1.7 (1.1–2.5)	0.008	0.9 (0.6–1.5)	0.82	2.2 (1.4–3.4)	0.0006	1.0 (0.6–1.8)	0.91
Cytogenetics
Favorable	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
Neutral	2.8 (2.5–3.3)	<0.0001	2.1 (1.8–2.5)	<0.0001	4.1 (3.3–5.1)	<0.0001	2.9 (2.3–3.8)	<0.0001
Unfavorable	6.9 (5.7–8.2)	<0.0001	3.6 (2.9–4.5)	<0.0001	11.8 (9.3–15.2)	<0.0001	5.8 (4.3–7.9)	<0.0001
End of induction BM MRD
<0.01%	Ref	Ref	Ref	Ref	Ref	Ref	Ref	Ref
≥0.01%	3.7 (3.3–4.1)	<0.0001	2.9 (2.5–3.2)	<0.0001	4.3 (3.7–5.0)	<0.0001	2.9 (2.5–3.4)	<0.0001

95CI – 95% confidence interval; BM – bone marrow; CNS – central nervous system; HR – hazard ratio; MRD – minimal residual disease; WBC – white blood cells