Table 2.

Logistic Regression Models for TB Infection (n/N=160/279) in Child Household Contacts of Adults with Pulmonary RR-TB

	n/N (%) 160/279 (57%)	Univariable		Multivariable
Characteristic		Odds Ratio (95% CI)	P	Odds Ratio (95% CI)	P
Household Contact Characteristics
HHC Age			0.10
< 5 years	43/88 (49%)	0.5 (0.3, 0.9)	0.03
5 - 9 years	62/104 (60%)	0.9 (0.6, 1.5)	0.77
10 - 14 years	55/87 (63%)	1.0 ref
HHC Sex			0.35
Male	88/145 (61%)	1.3 (0.8, 2.0)
Female	72/134 (54%)	1.0 ref
HHC Age and School Attendance			0.033		0.013
Age <5 years	43/88 (49%)	1.0 ref		1.0 ref
Age 5 - 14 years, Never in School	6/14 (43%)	0.9 (0.3, 2.3)	0.78	0.9 (0.3, 2.6)	0.89
Age 5 - 14 years, Currently or Ever in School	111/177 (63%)	2.0 (1.2, 3.5)	0.010	2.4 (1.4, 4.2)	0.003
Previous TB Treatment			0.77
Yes	5/9 (56%)	1.2 (0.3, 5.0)
No/Unknown	155/270 (57%)	1.0 ref
Index Participant Characteristics a
Index Participant Age			0.09		0.049
<25 years	46/78 (59%)	1.0 ref		1.0 ref
25 - 34 years	33/74 (45%)	0.5 (0.2, 1.0)	0.06	0.3 ( 0.1, 0.8)	0.010
35 - 49 years	63/95 (66%)	1.2 (0.6, 2.7)	0.58	0.8 ( 0.3, 1.9)	0.62
50+ years	18/32 (56%)	0.7 (0.3, 1.8)	0.69	0.6 ( 0.2, 1.8)	0.35
Index Participant Sex			0.74
Male	70/125 (56%)	0.9 (0.5, 1.6)
Female	90/154 (58%)	1.0 ref
Index Participant Smoking Status			0.07		0.034
Current	41/58 (71%)	1.9 (0.95, 3.9)		2.3 (1.02, 5.0)
Previous/Never	119/221 (54%)	1.0 ref		1.0 ref
Exposure Characteristics
Index Participant-HHC Relationship and Sleeping Arrangement		0.024			0.002
Mother/Father, Slept in Same Room	41/59 (69%)	2.8 (1.5, 5.5)	0.002	5.1 (2.4, 11)	<0.001
Mother/Father, Slept in Different Room	20/32 (63%)	2.2 (1.02, 4.9)	0.045	2.4 (1.1, 5.6)	0.037
Other Relationship, Slept in Same Room	35/57 (61%)	2.1 (1.0, 4.3)	0.05	2.6 (1.1, 5.7)	0.023
Other Relationship, Slept in Different Room	64/131 (49%)	1.0 ref		1.0 ref
Index Participant-HHC Relationship			0.009
Mother/Father	61/91 (67%)	2.0 (1.2, 3.4)
Other	99/188 (53%)	1.0 ref

Abbreviations: HHC, household contact; CI, confidence interval; P, overall p-value from score test, and for categorical variables with more than 2 categories Wald tests for pairwise comparisons to the reference category; n/N (%), number of HHCs positive on outcome/total with results (crude percentages that do not account for clustering within household); OR, odds ratio; ref, reference group.

Odds ratios, univariable or adjusted from multivariable models, are based on logistic regression using a generalized estimating equation approach to account for correlation among HHCs within a household.

^aCharacteristics of index participants according to TB infection status of their HHCs. An index participant with more than one HHC will contribute more than once to the sample counts.