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. Author manuscript; available in PMC: 2022 Apr 14.
Published in final edited form as: J Alzheimers Dis. 2022;86(3):1037–1059. doi: 10.3233/JAD-215546

Fig. 6.

Fig. 6.

Amyloid pathology in the hippocampus. Wild-type (WT, black) and TgF344-AD (AD, red) rats were injected bilaterally into the LC with AAV-PRSx8-hTau (hTau, hashed) or AAV-PRSx8-mCherry (mCherry, solid) at 2 months of age, and assessed for 4G8 (i.e., Aβ) immunoreactivity at 6 months or 12 months. N = 5–7 per group. Shown are representative images of amyloid pathology in the DG subregion of the hippocampus (A), and quantification of amyloid pathology in the DG (B), CA3 (C), and CA1 (D) expressed as % region of interest (ROI). Main images and insets taken at 10x and 40x magnification, respectively. ***p<0.001, ****p<0.0001. Males are represented by closed circles, females by open circles.