Scheme 1.
Reagents and conditions: (a) DCM, MeOH, Na(AcO)3BH, r.t, overnight; (b) i)1M. NaOH aq., MeOH, r.t, 48h, ii) dil. HCl; (c) PyBOP, DIPEA, H2NOTHP, THF, r.t, overnight; d) catalytic. HCl, THF, r.t, overnight.
Reagents and conditions: (a) DCM, MeOH, Na(AcO)3BH, r.t, overnight; (b) i)1M. NaOH aq., MeOH, r.t, 48h, ii) dil. HCl; (c) PyBOP, DIPEA, H2NOTHP, THF, r.t, overnight; d) catalytic. HCl, THF, r.t, overnight.