Skip to main content
. Author manuscript; available in PMC: 2023 Apr 12.
Published in final edited form as: Circulation. 2022 Mar 17;145(15):1140–1153. doi: 10.1161/CIRCULATIONAHA.121.056929

Figure 2. MiR-210 mimic exerts a protective effect on IR-induced MI and cardiac dysfunction.

Figure 2.

Male miR-210 knockout (KO) and their wild-type (WT) littermate control mice with C57Bl/6 background at 2 months old underwent myocardial infarction (MI) induced by in vivo heart ischemia and reperfusion (IR) treatment via ligation of the mid-left anterior descending coronary artery for 30 min followed by reperfusion. MiR-210 mimic (10 nmol/kg) or negative control was intravenously administered 1 h prior to the IR treatment. MI (A, B) and functional echocardiography (C, D) were evaluated 72 h after IR. Data are means ± SD, with n=5–8 animals per group, and analyzed by two-way ANOVA followed by Tukey’s test. P values are shown in the Figure.