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. 2022 Apr 13;12:6185. doi: 10.1038/s41598-022-09590-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Study design. DOTATATE biodistribution and pharmacokinetics were obtained by ex vivo gamma counting of organs, blood and blood fractions in healthy and atherosclerotic mice and rabbits. In mice, comparison of [⁶⁴Cu]Cu-DOTATATE and [¹⁸F]F-FDG in models of myocardial infarction and atherosclerosis was performed by in vivo PET/CT, while tracers’ cellular uptake was determined by fluorescence activated cell sorting (FACS) of digested heart and aortic tissue followed by gamma counting. In rabbits, animals were imaged by in vivo PET/MRI using [⁶⁸Ga]Ga-DOTATATE and [¹⁸F]F-FDG. Results were validated by ex vivo gamma counting and near-infrared fluorescence imaging.