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. 2022 Apr 13;12:6185. doi: 10.1038/s41598-022-09590-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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[⁶⁴Cu]Cu-DOTATATE pharmacokinetics and biodistribution in mice. (A) Blood time-activity curve for intravenously infused [⁶⁴Cu]Cu-DOTATATE in C57Bl/6 (left) and Apoe^−/− (right) mice. Data are presented as mean ± standard error of the mean. C57Bl/6 N = 7 and Apoe^−/− N = 6. (B) [⁶⁴Cu]Cu-DOTATATE radioactivity distribution in blood fractions as measured by gamma counting. Graphs show the percentage of activity associated with cells or plasma. Data are presented as mean ± standard error of the mean. N = 5 per group. (C) Percentage of activity associated with blood mononuclear or polynuclear cells. Data are presented as mean ± standard error of the mean. N = 5 per group. (D) Time-activity curves for [⁶⁴Cu]Cu-DOTATATE in clearance organs. N = 5 per group. (E) Gamma counting of [⁶⁴Cu]Cu-DOTATATE activity in the myocardium over time. Data are presented as median (interquartile range). C57Bl/6 N = 5 and Apoe^−/− N = 4. (F) Time-activity curves for [⁶⁴Cu]Cu-DOTATATE in the arch, thoracic and abdominal aorta. Data are presented as median (interquartile range). N = 5 per group. ID: injected dose; t_1/2: half-life.