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. 2022 Apr 13;12:6185. doi: 10.1038/s41598-022-09590-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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[⁶⁴Cu]Cu-DOTATATE PET imaging of murine myocardial infarction. (A) Representative fused [⁶⁴Cu]Cu-DOTATATE PET/CT 3D-rendered images of healthy (left) and LAD-ligated (right) animals. Blue arrows represent region of infarct. (B) [⁶⁴Cu]Cu-DOTATATE SUV_max (in vivo) and (C) %ID/g (ex vivo) in the heart of C57Bl/6 healthy animals (myocardium) and LAD-ligated mice (remote and infarct). N = 4 per group. (D) Representative fused [¹⁸F]F-FDG PET/CT 3D-rendered images of healthy (left) and LAD-ligated (right) animals. Blue arrows represent region of infarct. (E) [¹⁸F]F-FDG SUV_max (in vivo) and (F) %ID/g (ex vivo) in the heart of C57Bl/6 healthy animals (myocardium) and LAD-ligated mice (remote and infarct). Controls N = 4 and infarcted N = 6. (G) Representative flow cytometry plots identifying CD11b⁻, CD11b⁺ and macrophage cell populations in the myocardium. (H) Quantification of activity per cell in the infarcted myocardium. Data are expressed as ratio of CD11b⁺/CD11b⁻ (left) and Mφ/CD11b⁺ cell activity (right). N = 4 per group. DOTATATE: [⁶⁴Cu]Cu-DOTATATE; FDG: [¹⁸F]F-FDG; infarct: infarcted region of the myocardium; ID: injected dose; Mφ: macrophages; Myocardium: healthy C57Bl/6 myocardium; remote: remote myocardium (non-infarcted); SUV_max: maximum standardized uptake value. CD11b⁺ cells represent CD11b⁺CD11c^hi, excluding macrophage population. *p < 0.05. Data are presented as median (interquartile range).