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. 2022 Apr 13;12:6185. doi: 10.1038/s41598-022-09590-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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[⁶⁴Cu]Cu-DOTATATE PET imaging of murine atherosclerosis. (A) Representative fused PET/CT image of [⁶⁴Cu]Cu-DOTATATE-infused C57Bl/6 (left) and Apoe^−/− mice after 12 weeks on WD (right). Red dot represents origin of ascending aorta. (B) In vivo [⁶⁴Cu]Cu-DOTATATE SUV_max of the ascending aorta. N = 4 per group. (C) Ex vivo %ID/g of the whole aorta. N = 4 per group. (D) Representative fused PET/CT 3D-rendered image of [¹⁸F]F-FDG-infused Apoe^−/− mice. Red dot represents origin of ascending aorta. (E) [¹⁸F]F-FDG SUV_max of ascending aorta. N = 4 per group. (F) %ID/g of the whole aorta. N = 4 per group. (G) Representative flow cytometry plots identifying CD11b⁺ and macrophage cell populations in the aorta. (H) Quantification of activity per cell in the aorta. Data are expressed as ratio of CD11b⁺/CD11b⁻ (left) and Mφ/CD11b⁺ cell activity (right). N = 4 per group. DOTATATE: [⁶⁴Cu]Cu-DOTATATE; FDG: [¹⁸F]F-FDG; ID: injected dose; Mφ: macrophages; SUV_max: maximum standardized uptake value. CD11b⁺ cells represent CD11b⁺CD11c^hi, excluding macrophage population. *p < 0.05. Data are presented as median (interquartile range).