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. 2022 Apr 13;13(4):340. doi: 10.1038/s41419-022-04803-y

Fig. 7. 3PO suppresses the progression of glomerulopathy in db/db mice.

Fig. 7

A Schematics showing the experimental design. 3PO or DMSO was intraperitoneally injected into 9-week-old db/db and db/m mice. The mice were euthanized at 4 weeks postinjection for analysis (n = 6 mice per group). B, C Weekly blood glucose and ACR measurements of db/db and db/m mice. D Representative images of PAS-stained kidneys of db/db and db/m mice. Scale bar, 50 μm. E Quantification of the glomerular volume and mesangial matrix fraction per mouse; n = 6 mice. F Representative images of CD68 and CD206 immunofluorescence. Scale bar, 50 μm. G Quantification of CD68- and CD206-positive cells in db/db and db/m mice. H RT–PCR analysis of the mRNA levels of ICAM-1, TNF-α, IL-6, and MCP-1 in db/m and db/db mice. n = 6 mice. The data are shown as the mean ± SD. **P < 0.01, ***P < 0.001; #P < 0.05, ##P < 0.01, ###P < 0.001.