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. 2022 Apr 13;13(4):342. doi: 10.1038/s41419-022-04807-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Clustered heatmap showing differentially expressed eccDNAs in paired primary tissues and metastatic tissues of four HGSOC patients. Red, up-regulation; Blue, down-regulation. B The SEM images of extracted eccDNAs in HGSOC tissues and ovarian cancer cell lines SKOV3, A2780 and OVCAR3. Scale bar, 1 μm. C The TEM images of eccDNAs in HGSOC tissues, SKOV3, A2780, and OVCAR3 cells. Scale bars, 2 μm and 1 μm. All imaging experiments were repeated at least three times, with similar results.