FIG. 3.
Effect of the number of administrations of RFB formulations per week on the growth indices for the livers (black bars) and spleens (white bars) of BALB/c mice infected with M. avium. Mice were intravenously infected with 200 μl of an M. avium inoculum at a concentration of 106 CFU per ml. Treatment started 2 weeks after infection. Mice were treated with a dose of 20 mg/kg, with the RFB formulations intravenously administered two or three times a week for 3 weeks. Values are means ± standard deviations for at least six animals for each group studied. The lipid composition of the liposomes was PC-PS at a molar ratio of 7:3. The mean liposome diameter was 0.3 μm (VET300).