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. 2022 Apr 13;13(4):344. doi: 10.1038/s41419-022-04699-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Representative images of internalization of serum-EVs by U251 and LN229 cells under a fluorescence microscope. B RT-qPCR detection of HOTAIR expression in U251 and LN229 cells co-cultured with GBM-serum-EVs and healthy-serum-EVs. **p < 0.01. C Invasion of U251 and LN229 cells co-cultured with GBM-serum-EVs and healthy-serum-EVs measured by Transwell assay. **p < 0.01, ***p < 0.001. D Colony formation of U251 and LN229 cells co-cultured with GBM-serum-EVs and healthy-serum-EVs measured by colony formation assay. ****p < 0.0001. E HOTAIR expression in the GSE100736 data set. F IC50 of U251, U251/TR, LN229, and LN229/TR cells co-cultured with GBM-serum-EVs and healthy-serum-EVs measured by CCK-8. G RT-qPCR detection of HOTAIR expression in TMZ-resistant U251/TR and LN229/TR cells and its parental cells U251 and LN229. **p < 0.01, ***p < 0.001. H Colony formation of U251/TR and LN229/TR cells are co-cultured with GBM-serum-EVs and healthy-serum-EVs measured by colony formation assay. **p < 0.01, ***p < 0.001. I Flow cytometric analysis of apoptosis of U251/TR and LN229/TR cells co-cultured with GBM-serum-EVs and healthy-serum-EVs. ****p < 0.0001, compared with cells treated with DMSO. ^#p < 0.05, compared with healthy-serum-EVs. Each experiment was repeated three times independently.