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. 2022 Apr 13;13(4):344. doi: 10.1038/s41419-022-04699-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A The predicted binding sites between HOTAIR and miR-526b-3p by the starBase database. B Binding between miR-526b-3p and HOTAIR confirmed by dual-luciferase reporter assay. C Enrichment of HOTAIR in U251 cells transfected with Bio-miR-526b-3p-WT or Bio-miR-526b-3p-MUT assessed by RNA pull-down assay. D Binding between HOTAIR and miR-526b-3p analyzed by RIP assay. E FISH analysis of subcellular localization of HOTAIR and miR-526b-3p in U251 cells. F RT-qPCR detection of miR-526b-3p expression in U251 cells treated oe-HOTAIR or sh-HOTAIR. **p < 0.01, ***p < 0.001 or ****p < 0.0001. ns indicates no significant difference between the two groups. Each experiment was repeated three times independently.