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. 2022 Apr 13;13(4):344. doi: 10.1038/s41419-022-04699-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Venn diagram of downstream genes of miR-526b-3p predicted by the starBase and miRWalk databases, the top 500 survival-related genes, and TMZ resistance-related genes from the GSE100736 data set. B A box plot of EVA1 expression in TCGA-GBM. The red box on the left indicates GBM samples, and the gray box on the right indicates normal samples. C Correlation analysis of EVA1 expression with the overall survival of GBM patients in TCGA-GBM. D EVA1 expression in the TMZ resistance-related GSE100736 data set. E The predicted binding sites between miR-526b-3p and EVA1 by the starBase database. F Binding of miR-526b-3p to EVA1 confirmed by dual-luciferase reporter assay. G RT-qPCR and western blot analysis detection of EVA1 expression in U251 cells transfected with miR-526b-3p mimic or miR-526b-3p inhibitor. *p < 0.05, **p < 0.01, or ***p < 0.001. ns indicates no significant difference between the two groups. Each experiment was repeated three times independently.