Fig. 2.

Frequency of clinically significant cognitive impairments. (A) Proportion of patients with clinically relevant global or selective cognitive impairments using a cut-off for global impairment (dark red) defined as SCIP Total scores ≥1 below demographically adjusted norms and – for selective impairments (light red) – performance ≥1 SD below the demographically adjusted norms, on ≥2 individual tests. (B) Finally, proportion of patients with clinically relevant global or selective cognitive impairments using a cut-off for global impairment defined as SCIP Total scores ≥1 below 55 age- and education matched healthy controls (HC) following repeated testing and – for selective impairments – performance ≥1 SD below HC ≥2 individual tests. Dark red = global cognitive impairment; light red= selective cognitive impairment; green = cognitively normal.